{"product_id":"comboline-cats-18-pip-merial","title":"Comboline Cats 18 Pip Merial","description":"\u003ch2\u003eWhat is Comboline® Spot-On for CATS and CATS \u0026amp; FOXES?\u003c\/h2\u003e\n\u003cp\u003eAn external anti-parasitic topical solution for cats and ferrets.\u003cbr\u003ePharmaceutical form\u003cbr\u003eSolution for spot-on dorsal anointing (Sol.u.d.p.)\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eComposition per pipette \u003c\/strong\u003e(0.5 ml):\u003cbr\u003eFipronil 50 mg; (S)-methoprene 60 mg.\u003cbr\u003eExcipients: Butylated hydroxyanisole (E 320) 0.1 mg; butylated hydroxytoluene (E 321) 0.05 mg.\u003c\/p\u003e\n\u003ch2\u003ePharmacological properties\u003c\/h2\u003e\n\u003cp\u003ePharmacotherapeutic group: Topical ectoparasiticides QP53.\u003cbr\u003e\u003cbr\u003ePharmacodynamic properties: Fipronil is an insecticide\/acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-regulated chloride channels, in particular those regulated by the neurotransmitter ?-aminobutyric acid (GABA), blocking the pre- and postsynaptic transfer of chloride ions across the cell membrane. This results in uncontrolled central nervous system activity and death of the insects and mites. Fipronil kills fleas within 24 hours, and ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, lxodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours after exposure.\u003cbr\u003e\u003cbr\u003e(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes abnormal development and death at different stages of flea development. The ovicidal activity of (S)-methoprene occurs both by direct penetration into the shells of newly laid eggs and by absorption through the cuticle of adult fleas. (S)-methoprene is also effective in preventing the development of flea larvae and pupae, thus preventing contamination of the environment of treated animals by immature flea stages.\u003c\/p\u003e\n\u003ch2\u003ePharmacokinetic data\u003c\/h2\u003e\n\u003cp\u003eMetabolism studies of fipronil have shown that the main metabolite is the sulphone derivative of fipronil.\u003cbr\u003e\u003cbr\u003e(S)-methoprene is extensively degraded to carbon dioxide and acetate, which are then incorporated into endogenous materials.\u003cbr\u003e\u003cbr\u003eThe pharmacokinetic profiles after topical application in cats of fipronil and (S)-methoprene in combination have been studied in comparison to intravenous administrations of fipronil or (S)-methoprene alone. This established absorption and other pharmacokinetic parameters under similar clinical conditions. Topical application, with the additional potential oral exposure from licking, resulted in low systemic absorption of fipronil (18%) with a mean maximum concentration (Cmax) of approximately 100 ng\/ml of fipronil and 13 ng\/ml of its sulphone derivative in plasma.\u003cbr\u003e\u003cbr\u003ePeak plasma concentrations of fipronil are reached rapidly (mean tmax approximately 6 h), and decrease with a mean terminal half-life of approximately 25 h. Fipronil is slightly metabolised to fipronil sulphone in cats.\u003cbr\u003e\u003cbr\u003ePlasma concentrations of (S)-methoprene after topical application in cats were below the limit of quantification (20 ng\/ml).\u003cbr\u003e\u003cbr\u003e(S)-methoprene and fipronil, together with its major metabolite, are well destroyed by the fur of cats one day after application. Concentrations of both fipronil and its sulphone derivative and (S)-methoprene in the coat decrease over time and are detectable for at least 59 days after treatment. Parasites are killed by contact rather than systemic exposure.\u003cbr\u003e\u003cbr\u003eNo pharmacological interaction between fipronil and (S)-methoprene has been observed.\u003cbr\u003e\u003cbr\u003eThe pharmacokinetic profile of the veterinary medicinal product has not been investigated in ferrets.\u003c\/p\u003e\n\u003ch2\u003eInteractions and incompatibilities\u003c\/h2\u003e\n\u003cp\u003eNone known.\u003c\/p\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCats\u003c\/strong\u003e: Can be used against flea infestations, alone or in association with ticks and\/or biting lice.\u003cbr\u003e\u003cbr\u003e- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new adult flea infestations persists for 4 weeks. Prevention of flea multiplication by inhibition of the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six weeks after application.\u003cbr\u003e\u003cbr\u003e- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). Acaricidal efficacy of up to 2 weeks against ticks (based on experimental data).\u003cbr\u003e\u003cbr\u003e- Elimination of biting lice (Felicola subrostratus).\u003cbr\u003e\u003cbr\u003eCan be used as part of the treatment strategy for the control of flea allergy dermatitis (FAD).\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eFerrets\u003c\/strong\u003e: Can be used against flea infestations, alone or in association with ticks.\u003cbr\u003e\u003cbr\u003e- Flea (Ctenocephalides spp.) elimination. Insecticidal efficacy against new adult flea infestations persists for 4 weeks. Prevention of flea multiplication by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.\u003cbr\u003e\u003cbr\u003e- Elimination of ticks (Ixodes ricinus). Acaricidal efficacy persists for up to 4 weeks against ticks (based on experimental data).\u003c\/p\u003e\n\u003ch2\u003eContraindications\u003c\/h2\u003e\n\u003cp\u003eIn the absence of available data, not for use in kittens less than 8 weeks of age and\/or weighing less than 1 kg.\u003cbr\u003e\u003cbr\u003eNot for use in ferrets less than 6 months of age.\u003cbr\u003e\u003cbr\u003eDo not use in sick (systemic disease, fever, etc.) or convalescent animals.\u003cbr\u003e\u003cbr\u003eDo not use in rabbits, as adverse reactions, even life-threatening, may occur.\u003cbr\u003e\u003cbr\u003eIn the absence of studies, use in non-target species is not recommended.\u003cbr\u003e\u003cbr\u003eDo not use in cases of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003ch2\u003eAdverse reactions\u003c\/h2\u003e\n\u003cp\u003eAdminister the recommended dose.\u003cbr\u003eVery rare adverse reactions reported include: transient skin reactions at the site of application (scaling, local hair loss, itching, redness) as well as general itching or hair loss. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs) or vomiting have also been observed.\u003cbr\u003e\u003cbr\u003eIn case of licking, a brief period of excessive salivation may be observed mainly due to the nature of the excipient.\u003c\/p\u003e\n\u003ch2\u003eRoute of administration\u003c\/h2\u003e\n\u003cp\u003eDorsal spot-on solution.\u003c\/p\u003e\n\u003ch2\u003ePosology\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCats\u003c\/strong\u003e: One 0.5 ml pipette per cat corresponding to the recommended minimum dose of 5 mg\/kg fipronil and 6 mg\/kg (S)-methoprene, by topical application to the skin.\u003cbr\u003e\u003cbr\u003eIn the absence of safety studies, the minimum treatment interval is 4 weeks.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eFerrets\u003c\/strong\u003e: One 0.5 ml pipette per ferret corresponding to a dose of 50 mg fipronil and 60 mg (S)-methoprene per ferret, by topical application to the skin.\u003cbr\u003e\u003cbr\u003eThe minimum treatment interval is 4 weeks.\u003c\/p\u003e\n\u003ch2\u003eMethod of administration\u003c\/h2\u003e\n\u003cp\u003eHold the pipette in an upright position. Tap the narrow end of the pipette to ensure that the contents are in the main part of the pipette. Open the tip. Part the animal's hair at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times until the contents are completely emptied directly onto the skin in a single point.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e:\u003cbr\u003e\u003cbr\u003eIt is important to ensure that the veterinary medicinal product is applied to an area where the animal cannot lick itself and that animals do not lick each other after treatment.\u003cbr\u003e\u003cbr\u003eNo data are available on the effect of water immersion\/soapy baths on the efficacy of the veterinary medicinal product in cats and ferrets. However, based on the information available in shampooed dogs from 2 days after application of the veterinary medicinal product, it is not recommended to bathe animals within 2 days after application of the veterinary medicinal product.\u003cbr\u003e\u003cbr\u003eSingle tick attachment may occur. For this reason, transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.\u003cbr\u003e\u003cbr\u003eAnimal fleas often infest the basket, bedding and resting areas of animals, such as carpets and certain types of furniture which should be treated, in case of massive infestation, with an appropriate insecticide, at the beginning of control measures and regularly vacuumed.\u003cbr\u003e\u003cbr\u003eNo data are available on the potential toxicity of the veterinary medicinal product to kittens less than 8 weeks old in contact with a treated cat. Particular care should be taken in this case.\u003cbr\u003e\u003cbr\u003eSpecific precautions to be taken by the person administering the veterinary medicinal product to animals:\u003cbr\u003e\u003cbr\u003eThis veterinary medicinal product may cause eye, skin and mucosal irritation. Therefore, contact of the veterinary medicinal product with the mouth, skin and eyes should be avoided.\u003cbr\u003e\u003cbr\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product. Avoid contact of the veterinary medicinal product with the fingers. If this occurs, wash hands with soap and water.\u003cbr\u003e\u003cbr\u003eAfter accidental eye exposure, rinse the eye gently with water. Wash hands after use.\u003cbr\u003e\u003cbr\u003eTreated animals should not be touched until the application site of the veterinary medicinal product is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals should not be treated during the day, but should be treated in the evening, and that these newly treated animals should not sleep with owners, especially children.\u003cbr\u003e\u003cbr\u003eUse during pregnancy and lactation:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCats\u003c\/strong\u003e: Can be used during gestation.\u003cbr\u003e\u003cstrong\u003eFerrets\u003c\/strong\u003e: The safety of the product has not been established in ferrets during pregnancy and lactation. Use only in accordance with the benefit\/risk assessment carried out by the responsible veterinarian.\u003c\/p\u003e\n\u003ch2\u003eStorage instructions\u003c\/h2\u003e\n\u003cp\u003eDo not store above 30 °C. Store in the original container.\u003c\/p\u003e\n\u003ch2\u003eRemarks\u003c\/h2\u003e\n\u003cp\u003eMedicinal product not subject to veterinary prescription.\u003c\/p\u003e","brand":"COMBOLINE","offers":[{"title":"Default title","offer_id":43539598966961,"sku":"CO1436","price":85.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0638\/8829\/4065\/files\/comboline-gatos-18-pipetas-merial_34922a84-d397-4977-89a5-ab849f07775b.webp?v=1784335786","url":"https:\/\/farmaciasdirect-eu.myshopify.com\/products\/comboline-cats-18-pip-merial","provider":"Farmaciasdirect.eu","version":"1.0","type":"link"}