{"product_id":"tevagen-dexketoprofen-25-mg-10-tablet-coated-tablets","title":"Tevagen Dexketoprofen 25 mg, 10 coated tablets","description":"\u003ch2\u003eWhat is Tevagen Dexketoprofen 25 mg, 10 film-coated tablets and what is it for?\u003c\/h2\u003e\n\u003cp\u003ePain of mild to moderate intensity, such as musculoskeletal pain, dysmenorrhoea, odontalgia.\u003c\/p\u003e\n\u003ch2\u003eWho it is intended for\u003c\/h2\u003e\n\u003cp\u003eAdults over 18 years of age.\u003c\/p\u003e\n\u003ch2\u003eInstructions for use\u003c\/h2\u003e\n\u003cp\u003eOral use:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAdults: 12.5 mg\/4-6 h or 25 mg\/8 h, not exceeding 75 mg\/day.\u003c\/li\u003e\n\u003cli\u003eElderly: it is advisable to start with 50 mg daily, and may be increased to the adult dosage once good tolerability has been established.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eContraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eKnown hypersensitivity to dexketoprofen or allergy to aine.\u003c\/li\u003e\n\u003cli\u003ePatients with a history of hypersensitivity to acetylsalicylic acid or other NSAIDs, including patients who have experienced asthma attacks, acute rhinitis, urticaria or angioneurotic oedema after use of acetylsalicylic acid or other NSAIDs.\u003c\/li\u003e\n\u003cli\u003eGastrointestinal bleeding, oesophageal bleeding, active peptic ulcer, cerebral haemorrhage.\u003c\/li\u003e\n\u003cli\u003eRenal insufficiency: patients with moderate to severe renal insufficiency (ClCr \u0026lt; 50 ml\/min).\u003c\/li\u003e\n\u003cli\u003eHepatic insufficiency: patients with severe hepatic dysfunction (Child-Pugh score 10 - 15).\u003c\/li\u003e\n\u003cli\u003eDuring the third trimester of pregnancy or lactation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003ePharmacokinetics\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAbsorption:\u003c\/strong\u003e Rapidly absorbed through the gastrointestinal tract after oral administration, with peak plasma concentration obtained in 0.5-0.75 h (Tmax). Oral absorption is good. Following im administration in humans, Cmax is reached within 20 min (range 10-45 min). For single doses of 25 and 50 mg, the area under the curve has been shown to be dose proportional after im and iv administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDistribution:\u003c\/strong\u003e As with other drugs with high plasma protein binding (99 %), the volume of distribution averages less than 0.25 l\/kg and is selectively distributed in the body. The distribution half-life value was approximately 0.35 hours.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolism:\u003c\/strong\u003e Glucuronoconjugation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElimination:\u003c\/strong\u003e Excreted via the kidneys (80%) in the form of metabolites conjugated with glucuronic acid. After administration of dexketoprofen trometamol, only the S(+) enantiomer is obtained in urine, demonstrating that no conversion to the R-(-) enantiomer occurs in humans. The elimination half-life is 1-2.7 h.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003ePharmacokinetics in special situations\u003c\/h2\u003e\n\u003cp\u003eElderly: in healthy elderly individuals (65 years and older), exposure was significantly higher than in young volunteers after single and repeated doses administered orally (up to 55%), while there were no significant differences in Cmax and tmax. The elimination half-life was prolonged after single and repeated doses (up to 48%) and the apparent total clearance was reduced.\u003c\/p\u003e\n\u003ch2\u003eSide effects\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcne\u003c\/li\u003e\n\u003cli\u003eAgranulocytosis\u003c\/li\u003e\n\u003cli\u003eAnaphylaxis\u003c\/li\u003e\n\u003cli\u003eAnaemia\u003c\/li\u003e\n\u003cli\u003eAplastic anaemia\u003c\/li\u003e\n\u003cli\u003eHaemolytic anaemia\u003c\/li\u003e\n\u003cli\u003eAngioedema\u003c\/li\u003e\n\u003cli\u003eAnorexia\u003c\/li\u003e\n\u003cli\u003eAsthenia\u003c\/li\u003e\n\u003cli\u003eIncreased serum creatinine\u003c\/li\u003e\n\u003cli\u003eIncreased urea nitrogen\u003c\/li\u003e\n\u003cli\u003eIncreased transaminases\u003c\/li\u003e\n\u003cli\u003eMuscle cramps\u003c\/li\u003e\n\u003cli\u003eHeadache\u003c\/li\u003e\n\u003cli\u003eKetonuria\u003c\/li\u003e\n\u003cli\u003eMedullary depression\u003c\/li\u003e\n\u003cli\u003eDermatitis\u003c\/li\u003e\n\u003cli\u003eDiarrhoea\u003c\/li\u003e\n\u003cli\u003eDyspnoea\u003c\/li\u003e\n\u003cli\u003eDyspepsia\u003c\/li\u003e\n\u003cli\u003ePain\u003c\/li\u003e\n\u003cli\u003eAbdominal pain\u003c\/li\u003e\n\u003cli\u003ePain at the injection site\u003c\/li\u003e\n\u003cli\u003eEdema\u003c\/li\u003e\n\u003cli\u003eMalleolar oedema\u003c\/li\u003e\n\u003cli\u003eSkin rashes\u003c\/li\u003e\n\u003cli\u003eChills\u003c\/li\u003e\n\u003cli\u003eBronchial spasm\u003c\/li\u003e\n\u003cli\u003eConstipation\u003c\/li\u003e\n\u003cli\u003eExtrasystole\u003c\/li\u003e\n\u003cli\u003eGlomerulonephritis\u003c\/li\u003e\n\u003cli\u003eHeat stroke\u003c\/li\u003e\n\u003cli\u003eHaematemesis\u003c\/li\u003e\n\u003cli\u003eGastrointestinal bleeding\u003c\/li\u003e\n\u003cli\u003eHepatitis\u003c\/li\u003e\n\u003cli\u003eHyperglycaemia\u003c\/li\u003e\n\u003cli\u003eHyperhidrosis\u003c\/li\u003e\n\u003cli\u003eHyperkalaemia\u003c\/li\u003e\n\u003cli\u003eHypertension\u003c\/li\u003e\n\u003cli\u003eHypertriglyceridaemia\u003c\/li\u003e\n\u003cli\u003eHypoglycaemia\u003c\/li\u003e\n\u003cli\u003eHyponatremia\u003c\/li\u003e\n\u003cli\u003eHypotension\u003c\/li\u003e\n\u003cli\u003eJaundice\u003c\/li\u003e\n\u003cli\u003eInsomnia\u003c\/li\u003e\n\u003cli\u003eAcute renal failure\u003c\/li\u003e\n\u003cli\u003eRespiratory failure\u003c\/li\u003e\n\u003cli\u003eLow back pain\u003c\/li\u003e\n\u003cli\u003eDizziness\u003c\/li\u003e\n\u003cli\u003eAseptic meningitis\u003c\/li\u003e\n\u003cli\u003eNausea\u003c\/li\u003e\n\u003cli\u003eToxic epidermal necrolysis\u003c\/li\u003e\n\u003cli\u003eRenal medullary necrosis\u003c\/li\u003e\n\u003cli\u003eInterstitial nephritis\u003c\/li\u003e\n\u003cli\u003eNeutropenia\u003c\/li\u003e\n\u003cli\u003ePancreatitis\u003c\/li\u003e\n\u003cli\u003eParesthesia\u003c\/li\u003e\n\u003cli\u003eIntestinal perforation\u003c\/li\u003e\n\u003cli\u003ePolyuria\u003c\/li\u003e\n\u003cli\u003eProteinuria\u003c\/li\u003e\n\u003cli\u003ePruritus\u003c\/li\u003e\n\u003cli\u003ePurpura\u003c\/li\u003e\n\u003cli\u003ePhotosensitivity reactions\u003c\/li\u003e\n\u003cli\u003eJoint stiffness\u003c\/li\u003e\n\u003cli\u003eMuscle stiffness\u003c\/li\u003e\n\u003cli\u003eDry mouth\u003c\/li\u003e\n\u003cli\u003eSyncope\u003c\/li\u003e\n\u003cli\u003estevens-johnson syndrome\u003c\/li\u003e\n\u003cli\u003eNephrotic syndrome\u003c\/li\u003e\n\u003cli\u003eHot flushes\u003c\/li\u003e\n\u003cli\u003eDrowsiness\u003c\/li\u003e\n\u003cli\u003eTachycardia\u003c\/li\u003e\n\u003cli\u003eTinnitus\u003c\/li\u003e\n\u003cli\u003eMenstrual cycle disorders\u003c\/li\u003e\n\u003cli\u003eThrombocytopenia\u003c\/li\u003e\n\u003cli\u003eThrombophlebitis\u003c\/li\u003e\n\u003cli\u003eDuodenal ulcer\u003c\/li\u003e\n\u003cli\u003eGastric ulcer\u003c\/li\u003e\n\u003cli\u003eUrticaria\u003c\/li\u003e\n\u003cli\u003eBlurred vision\u003c\/li\u003e\n\u003cli\u003eVomiting\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003ePrecautions\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal insufficiency:\u003c\/strong\u003e It is excreted in urine, so accumulation may occur in case of renal insufficiency. In addition, it may lead to decreased renal blood flow with reversible acute renal failure due to inhibition of vasodilator prostaglandin synthesis, and cases of nephrotic syndrome and acute interstitial nephritis have even been reported with prolonged treatment. Patients with a higher risk of renal failure are those with previous renal failure, the elderly or situations that could reduce renal flow, such as hypovolaemia, dehydration, low sodium diets, heart failure, liver failure, liver cirrhosis or treatment with diuretics, ACE inhibitors or ARBs. In high-risk patients, during prolonged treatment, it is recommended to determine renal function (serum creatinine, CrCl) before starting treatment, and periodically. In case of worsening renal function, a dose reduction may be necessary. In patients with mild renal impairment, it is recommended to start treatment with a lower total daily dose, with careful monitoring of the patient. Use in moderate or severe renal impairment (CLcr \u0026lt; 50 ml\/min) is contraindicated.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic insufficiency:\u003c\/strong\u003e Due to hepatic metabolism, accumulation may occur in hepatic insufficiency. In patients with mild to moderate hepatic impairment (Child-Pugh class A or B), an initial dose of no more than 50 mg\/day is recommended, with careful monitoring of the patient. Use in severe insufficiency (class C or Child-Pugh score 10-15) is contraindicated. On the other hand, the use of aine has sometimes been associated with the development of hepatic symptoms, such as increased transaminases, jaundice and hepatitis, which can be severe and even fatal. Due to the risk of toxicity, patients with liver disease are advised to use this drug at the lowest effective dose, and to regularly check liver function (transaminases, bilirubin) for any signs of liver damage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal toxicity:\u003c\/strong\u003e Treatment with aine has resulted in gastroduodenal ulcers, as well as life-threatening bleeding and perforation. There is an increased risk of ulceration with high-dose or long-term treatment, with a history of peptic ulceration, especially if they have already had gastrointestinal bleeding or perforation from aine, as well as in smoking, chronic alcoholism or elderly or debilitated patients. However, short-term treatment is also not without risk.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eComposition\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eDexketoprofen trometamol: 36.91 mg dexketoprofen trometamol, equivalent to 25 mg dexketoprofen base.\u003c\/li\u003e\n\u003cli\u003eMaize starch (excipient)\u003c\/li\u003e\n\u003cli\u003ePotato carboxymethyl starch (E-468) (excipient).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003ePharmaceutical advice\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eThe patient should inform the doctor if he\/she experiences skin rash, symptoms that could be related to a gastroduodenal ulcer (such as epigastric pain or dark stools), visual disturbances, weight gain, oedema or prolonged headache.\u003c\/li\u003e\n\u003cli\u003eAs a general rule to reduce gastric damage, it is advisable to administer any aine with food. In addition, in risk groups it is advisable to start treatment with the lowest possible dose, and whenever possible to combine it with an anti-ulcer drug (anti-H2 or PPI).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat is the price of Tevagen Dexketoprofen 25 mg, 10 film-coated tablets?\u003c\/h2\u003e\n\u003cp\u003eThe price of over-the-counter medicines is set by law. However, at Farmaciasdirect you can buy Tevagen Dexketoprofen 25 mg, 10 coated tablets at a discount of up to 10%, which is the legal maximum allowed.\u003c\/p\u003e","brand":"TEVA","offers":[{"title":"Default title","offer_id":44438329950385,"sku":"TE8470007632887","price":3.43,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0638\/8829\/4065\/files\/tevagen-dexketoprofeno-25-mg-10-comprimidos-recubiertos.webp?v=1784374737","url":"https:\/\/farmaciasdirect-eu.myshopify.com\/products\/tevagen-dexketoprofen-25-mg-10-tablet-coated-tablets","provider":"Farmaciasdirect.eu","version":"1.0","type":"link"}